|
KMID : 0811720170210060617
|
|
Korean Journal of Physiology & Pharmacology
2017 Volume.21 No. 6 p.617 ~ p.623
|
|
|
Taurine relaxes human radial artery through potassium channel opening action
|
|
Ulusoy Kemal Gokhan
Kaya Erkan
Karabacak Kubilay
Seyrek Melik
Duvan Ibrahim
Yildirim Vedat
Yildiz Oguzhan
|
|
|
Abstract
|
|
|
|
The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 μM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 μM to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K+ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 μM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride?induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance Ca2+-activated K+ channels may be involved in taurine ?induced relaxation of RA.
|
|
|
KEYWORD
|
|
|
Potassium Channel, Radial Artery, Taurine, Vasodilation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|